In this nearly 2.5-hour episode, Dr. Rhonda Patrick and Dr. Roger Seheult and Kyle Allred of MedCram make a thoughtful, merit-based, and truly comprehensive discussion of COVID-19 vaccination. In addition to being a co-founder of MedCram Medical Lectures, Dr. Roger Seheult is, as you will find out in the conversation, a boots on the ground, critical care pulmonologist. For Dr. Seheult, COVID-19 is not just theory. He sees real sick people and for that reason brings a very special context to this conversation. Furthermore, Dr. Seheult is also an academic and educator. He is an Associate Clinical Professor at the University of California, Riverside School of Medicine and an Assistant Clinical Professor at the School of Medicine and Allied Health at Loma Linda University. He is quadruple-board certified in Internal Medicine, Pulmonary Diseases, Critical Care Medicine and Sleep Medicine through the American Board of Internal Medicine. In this episode, we discuss: 06:58 - Vaccination in the young and healthy 12:25 - Risk of myocarditis 16:18 - Long-haul COVID 25:36 - Spike protein cytotoxicity 34:16 - Biodistribution 41:17 - COVID-19 Vaccine Adverse Event Reporting System (VAERS) 01:06:55 - Antibody-dependent enhancement 01:14:54 - Do the COVID-19 vaccines damage human fertility? 01:19:51 - mRNA vaccines altering human DNA 01:28:10 - Current ivermectin evidence 01:47:40 - Delta-variant and breakthrough infections 02:01:42 - Viral evolution (virulence vs. immune escape) 02:10:45 - T-cell immunity vs. antibody immunity Watch the annotated video: https://www.youtube.com/watch?v=pp-nPZETLTo Subscribe to MedCram on Apple Podcasts: https://podcasts.apple.com/us/podcast/medcram/id1564795918 Subscribe to MedCram on YouTube: https://www.youtube.com/channel/UCG-iSMVtWbbwDDXgXXypARQ

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#069 COVID Vaccine Myths, Questions, and Rumors with Rhonda Patrick and Roger Seheult

Dr. William ("Bill") Harris is one of the world's preeminent experts in the field of omega-3 fatty acid research. His work has focused on the roles that fatty acids in play in cardiovascular and neurocognitive health. The author of more than 300 scientific papers on fatty acids and health, Dr. Harris is a professor in the Department of Medicine in the Sanford School of Medicine at the University of South Dakota, the co-inventor of the Omega-3 Index, founder of OmegaQuant Analytics, and president and founder of the Fatty Acid Research Institute. In this episode, Dr. Harris and I discuss… 00:06:36 How early studies on dietary fats and cholesterol levels spawned the field of omega-3 research. 00:14:44 How standards of "normal" bleeding time may be abnormally high in Western countries, leading to some misconception on the effects of omega-3. 00:20:33 How different types of omega-3s, such as alpha-linolenic acid, share structural similarities with marine omega-3s but not the same cardioprotective effects. 00:25:23 How genetic engineering of plants may yield abundant, sustainable omega-3s in the future. 00:27:18 What the omega-3 index test is, how it was created, and how it reveals individual variations in how much omega-3 we may need. 00:32:13 How red blood cell concentration of omega-3s better reflect long-term omega-3 status. 00:36:41 How genetic variants influence omega-3 dietary needs. 00:54:20 How the omega-3 index may predict life expectancy. 01:05:03 How metabolites of omega-3 metabolism reduce and resolve inflammation. 01:17:11 How people with high omega-3 concentrations were half as likely to die from COVID-19. 01:20:10 How the omega-3 DHA may help keep the SARS-CoV-2 spike protein from entering cells. 01:22:50 How concerns over the omega-6/omega-3 ratio may be unfounded, and it really may boil down to just how much omega-3 you're taking in.   Looking for more?  Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#068 Dr. Bill Harris on omega-3 fatty acids, cardiovascular health, and inflammation

Dr. Ashley Mason is a clinical psychologist and director of the Sleep, Eating, and Affect Laboratory at the Osher Center for Integrative Medicine at UCSF. Her research centers on nonpharmacological approaches for treating depression, insomnia, and overeating. In this episode, you’ll hear Rhonda and Ashley discuss: 00:08:10 - How whole-body hyperthermia (WBH) and sauna use differ.  00:17:06 - How people with depression have thermoregulatory dysfunction – but sauna use may correct it. 00:21:12 - How WBH and sauna use may reduce symptoms of depression. 00:33:22 - How heating the body slowly may improve heat tolerance and increase WBH effectiveness.  00:39:35 - How sauna use may benefit people with depression and cardiovascular disease – which often coincide.  00:40:18 - How Dr. Mason and I are collaborating on a new research project to measure biomarkers associated with depression and WBH. 00:44:19 - How sauna bathing and similar practices often provide opportunities for people to connect socially.  00:53:12 - How insomnia differs from being a "night owl." 00:57:10 - How insomnia often arises from major changes in a person's life.  01:01:26 - How cognitive behavioral therapy, sleep hygiene, stimulus control, and sleep restriction can help treat insomnia without drugs.   and so much more!   Looking for more?  Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#067 Dr. Ashley Mason on Drug-free Approaches for Treating Depression, Insomnia, and Overeating

Dr. Mark Mattson Dr. Mark Mattson is a professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He's one of the most cited neuroscientists in the world, with more than 180,000 citations noted in the scientific literature. Dr. Mattson's work has advanced scientific understanding of brain aging and identified fundamental aspects of neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. His most notable work has focused on how the brain responds to mild stressors, such as those associated with exercise and intermittent fasting. In this episode, Dr. Mattson and I discuss... 00:3:31 How hormetic stressors drive adaptation and prevent physiological complacency. 00:13:00 How intermittent fasting improves health by promoting metabolic switching. 00:16:49 How daily time-restricted eating and 5:2 weekly fasting compare. 00:27:44 How a ketogenic diet and intermittent fasting differ in terms of brain effects. 00:34:23 How exercising while intermittent fasting exerts additive effects. 00:52:32 How plant-based bioactive compounds induce hormetic stress. 01:10:48 How severe caloric restriction may harm the body and compromise muscle mass. 01:26:25 The differing contexts of intermittent fasting: young vs. old and in men vs. in women. 01:35:20 How the effects of cortisol differ during a fast versus chronic uncontrollable stress. 01:53:36 How the effects of fasting-mimetics like resveratrol and spermidine compare with actual fasting, and; 02:08:44 How ketone supplementation may improve brain health   Show notes coming soon! Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#066 Dr. Mark Mattson on the Benefits of Stress, Metabolic Switching, Fasting, and Hormesis

Dr. Satchin Panda Dr. Satchidananda (Satchin) Panda is a professor in the Regulatory Biology Laboratory at the Salk Institute for Biological Studies.  Dr. Panda’s work focuses on chronobiology, the study of the day-night cycles that drive the multifaceted activities of the human body, using genetic, genomic, and biochemical approaches. He is an expert on circadian rhythms and a pioneer in the field of time-restricted eating. A priority for Dr. Panda when designing his studies is to identify strategies that positively impact public health. In this episode, Dr. Panda and I discuss... 00:05:31 How circadian rhythms influence human health. 00:12:30 How seeking bright light in the morning and avoiding it in the evening can help us sleep better. 00:20:40 How the ability of supplemental melatonin to counteract evening bright light exposure varies. 00:26:16 How understanding the relationship between melatonin and insulin secretion might help us decide when to eat. 00:33:15 How shift work, jet lag, and modern lifestyles contribute to altered circadian rhythms and metabolic dysfunction. 00:45:10 How naps might aid with afternoon sleepiness and sleep loss. 00:47:05 How we can tailor our indoor lighting environment to promote healthy circadian rhythms. 00:51:20 How time-restricted eating (eating within a narrow time range) can be beneficial. 01:02:13 How Dr. Panda’s ongoing study uses a smartphone app to track when people eat. 01:03:41 How most people are unaware of their eating patterns. 01:07:58 How Dr. Panda incorporates his research findings into his own life. 01:16:21 How our circadian rhythms dictate when we should exercise – and how caffeine provides a workaround.   If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/satchin-panda-3 Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#065 Dr. Satchin Panda on Circadian Insights into Exercise Timing, Melatonin Biology, and Peak Cognition

Michael Snyder Dr. Michael Snyder is the director for the Center for Genomics and Personalized Medicine at Stanford and a pioneer and advocate of "deep profiling." Deep profiling seeks to apply intelligent analysis to large data sets to yield specialized clinical insight, ranging from common consumer-grade wearables like Apple Watches to whole-body MRI, continuous glucose monitoring, and metabolomics. In this episode, you'll discover: 00:12:51 Continuous glucose monitors 00:31:04 Lyme disease 00:34:00 Predicting illness with smartwatches 00:39:14 Heart rate variability 00:40:41 Exposome and airborne pollutants 00:51:04 Discovering Ageotypes 00:58:05 Exercise benefits 01:03:11 Michael Snyder's lifestyle habits If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/michael-snyder Join over 300,000 people and get the latest distilled information on personalized medicine straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#064 Dr. Michael Snyder on Continuous Glucose Monitoring and Deep Profiling for Personalized Medicine

Dr. Roger Seheult Dr. Roger Seheult is the co-creator of MedCram Videos. In the early days of the COVID-19 pandemic, MedCram emerged as a beacon of insight, providing continuing coverage and perspectives in an environment almost defined by information scarcity.   What particularly excited me about the unique opportunity of this interview is that apart from Dr. Seheult being a unique voice of public scholarship during the early days of the pandemic, he's also a quadruple board-certified pulmonologist with deep experience working on the frontline of the COVID-19 pandemic. In this episode, you'll discover: 00:06:20 How MedCram Videos got started and the future of medical education from Dr. Seheult's standpoint. 00:09:37 What to do when life is on the line and the usual hierarchy of evidence doesn't exist, as in early emergency COVID-19 treatment. 00:12:46 The crucial differences in treating early vs. late-stage COVID-19 illness. 00:14:40 How doctors would've treated COVID-19 one-hundred years ago. 00:18:13 How increasing ventilation may powerfully impact COVID-19 disease transmission and why airplanes have surprisingly little disease transmission. 00:20:28 How masks are virtually universally beneficial in the pandemic regardless of type. 00:21:32 Vitamin D and COVID-19 00:22:22 How the steroid chemical structure of vitamin D confers qualities on vitamin D that other vitamins ("vital amines") do not possess, such as membrane permeability that provides access to the nucleus and broad gene regulatory effects mediated by a specialized vitamin D receptor element. 00:23:24 How calcium homeostasis, which was the early and exclusive focus for scientists and doctors that were trying to determine the ideal vitamin D levels, may have caused the RDA to be set too low since we now know vitamin D regulates around 5% of the protein-encoding genome and have much broader effects. 00:24:23 How the hormonal role of vitamin D confers on it properties more similar to other hormones like testosterone and cortisol rather than those of ordinary vitamins. 00:26:21 The surprising level of overlap between COVID-19 positivity and groups most affected by vitamin D deficiency and the surprise finding of how less than 50 ng/mL blood levels of vitamin D associated with greater likelihood of SARS-CoV-2 positivity in the hospital. 00:30:27 How scientists are able to interrogate the effects of low vitamin D levels through genetic research, a type of study known as mendellian randomization. 00:34:20 The gene regulatory effects of vitamin D and the implications for the scale of its biological impact. 00:35:49 How Vitamin D's ACE2/renin-angiontensin-promoting effects may be mechanistically involved in the effects observed in vitamin D COVID-19 studies. 00:42:00 Why ameliorating vitamin D deficiency in one large monthly bolus might be less effective than daily or weekly doses. 00:43:23 How a prescription-only form of vitamin D known as Calcifediol might have an advantage in acute care for COVID-19. 00:47:06 Why skin synthesis of vitamin D from UV B radiation can be extraordinarily unreliable when compared to supplementation. 00:53:43 What the safest dose range for vitamin D is that should also address deficiency in most populations. 01:06:15 The beneficial circadian effect of early morning sunlight. 01:07:38 How sleep deprivation is meaningfully implicated in profound and immediate impairment of viral immunity. 01:12:08 Dr. Seheult's suggestions for how to achieve the highest quality of sleep. 01:19:18 How a century old sanitarium technique used during the Spanish flu era massively boosts interferon by up to ten-times using heat exposure. 01:22:38 How genetic and antibody-induced failures of the interferon system underpin up to 14% of all severe cases of COVID-19 and why interferon is so vitally important for viral response. 01:26:43 Why treating the symptoms of fever during the spanish flu turned out to not be a good idea, immunologically speaking. 01:31:58 Dr. Seheult's on-going research into using hot hydrotherapy as a viral immunity booster. 01:47:00 COVID-19 Vaccines   If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/roger-seheult Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#063 Dr. Roger Seheult from MedCram on COVID-19 Vaccines, Vitamin D, and Heat Hydrotherapy

Steve Horvath Steve Horvath, PhD, is a professor of human genetics and biostatistics at UCLA's Fielding School of Public Health Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan.   If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/steve-horvath Join over 300,000 people and get the latest distilled information on aging straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#062 Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks

Dr. Jed Fahey In this special two-hour Q&A episode with Dr. Jed Fahey, a world-leading expert on the science of chemoprotection and, in particular, sulforaphane, we discuss many of the listener-submitted questions from the hundreds of live event participants.   In this episode, you'll discover: 00:07:19 - The minimum daily dose of sulforaphane that elicits beneficial health effects 00:12:04 - Why gauging the amount of sulforaphane in foods presents challenges 00:17:37 - Workarounds to enhance the sulforaphane in cooked foods 00:23:38 - How often to consume broccoli sprouts and how long their effects last 00:39:28 - The effects of sulforaphane on glutathione production in the brain 00:43:12 - The effects of sulforaphane on cancer 01:17:26 - Alternatives to sprouts, such as supplements (and which ones Dr. Fahey recommends) 01:33:08 - Safety concerns regarding sulforaphane   If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/jed-fahey-q-a Join over 300,000 people and get the latest distilled information  straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#061 Q&A with Dr. Jed Fahey on Sulforaphane, Moringa and Chemoprotection

Giselle Petzinger Giselle Petzinger, MD, an associate professor of Neurology at the University of Southern California, studies the extensive effects of how different types of exercise, in particular skill-based exercise, can affect the clinical outcome for people with Parkinson’s disease. Dr. Petzinger's work focuses on understanding how to promote brain repair after injury, particularly in the context of Parkinson's disease. She is currently investigating ways to enhance neuroplasticity in a preclinical model of the disease. She has examined the role of exercise in Parkinson's disease, with emphasis on how different types of exercise affect distinct regions of the brain. Her work has implications for improving the quality of life of patients diagnosed with the neurological disorder — a condition for which there is no cure.   In this episode, you'll discover: 00:06:57 What is Parkinson’s disease? 00:11:57 How symptoms of Parkinson’s disease generally only appear when ~50% of dopamine-secreting neurons in substantia nigra are lost. 1 00:14:57 How other circuits in the brain can compensate for the loss of function of the substantia nigra. 00:18:37 Prevalence and hereditary risk factors of Parkinson’s disease.  00:21:25 How epidemiological studies have linked increased Parkinson’s disease risk with exposure to pesticides, herbicides, solvents, and certain heavy metals such as manganese. 1  00:26:57 How exercise can lower the risk of developing Parkinson’s disease. 1 2 3 00:35:38 How skill-based exercise, such as yoga, Tai chi, boxing, tango or skateboarding may play a special role in ameliorating some of the effects of the disease by driving circuit-specific effects, by creating top-down cognitive challenge for skills involved in a patient's movement through space. 00:47:49 How serum BDNF significantly increases in Parkinson’s patients after 1 month of treadmill exercise and why this might mean better cognitive function. 1 2  00:58:33 How treadmill exercise with heart rate 80-85% maximum for at least 3x per week slowed the progression of Parkinson’s disease symptoms. 1 01:01:31 Why exercise may not fully replace the use of medications. 01:09:58 How the omega-3 fatty acid DHA has some preclinical evidence suggesting it may reduce motor-symptoms and dyskinesia in Parkinson’s disease. 1 2 3 4 01:12:12 How patients with Parkinson’s disease have higher levels of inflammatory biomarkers and how this might contribute to the disease. 1   If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/giselle-petzinger Join over 300,000 people and get the latest distilled information on parkinson's disease straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor  

#060 Dr. Giselle Petzinger on Exercise for Parkinson's Disease

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Fasting. What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed. This collection of clips covers a range of topics related to fasting, including associated mechanisms of healthspan and longevity, purported health benefits, and when and how to break the fast.   Learn more about our premium podcast feed The Aliquot by clicking here. Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#059 Aliquot #3: Q&A Mashup - Fasting

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Sauna use. What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.   Learn more about our premium podcast feed The Aliquot by clicking here. Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#058 Aliquot #2: Q&A Mashup - Sauna

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on pregnancy and child development. What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed. This particular collection of segments covers every single major discussion of pregnancy and child development spanning years of members-only Q&As. Just for a few examples, it covers... My pre-pregnancy regimen, including diet, exercise, vitamins and sleep Nutrition for babies and toddlers to maximize brain development and growth Extra precautions that I took during my pregnancy And much, much more!   Learn more about our premium podcast feed The Aliquot by clicking here. Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#057 Aliquot #1: Q&A Mashup - Pregnancy and child development

This episode aims to be the most comprehensive video compendium on the biology of breast milk ever recorded. In this episode, you'll discover: 00:07:11 - Breast milk composition and production 00:09:59 - Human milk oligosaccharides in breast milk establish the infant gut microbiome 00:15:48 - Omega-3 fatty acids and other components in breast milk boost brain development 00:18:14 - Vitamins and minerals in breast milk 00:22:05 - Breast milk stem cells and multi-organ microchimerism 00:22:54 - Harmful substances transferred to infant via breast milk 00:28:03 - The effects of breastfeeding on the infant's immune system 00:31:17 - Effects on intelligence 00:34:36 - Breastfeeding as a benefit to maternal health   If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/breast-milk Join over 300,000 people and get the latest distilled information on the biology of breast milk straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#056 The Biology of Breast Milk

This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the on-going pandemic and tried to add value by talking about some of the recent research, among other things. In this episode, you'll discover: 00:04:03 Data surrounding SARS-CoV-2 duration 00:06:37 SARS-CoV-2 and potential immunity 00:11:35 Some of the main factors known to play a role in immune variation 00:12:05 What role genetics may play in immune function 00:14:27 How previous viral exposure regulates immunity 00:15:05 What cross immunity is and how it may be relevant for SARS-CoV-2 00:19:46 Antibody-dependent enhancement and SARS-CoV-2 relevance 00:21:50 How sleep is a key regulator of immune function 00:23:44 Microbiome composition and immune function 00:28:31 The differential effects of exercise intensity and duration on immune regulation 00:35:00 How specific micronutrient inadequacies may promote immune dysregulation 00:47:20 The effect of sex hormones on immune function 00:48:55 How biological age age may play a role in immune regulation 00:49:46 Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19 00:53:15 ARDS and long-term lung damage   If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/covid-19-episode-2 Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#055 COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More

Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.

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